Senior Scientist I, In Vivo Target Discovery - 2452
Editas Medicine, United States
Job Description
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Editas Medicine is seeking a highly motivated and collaborative cell biologist to join our In Vivo Target Discovery Research group. In this role, you will support on-going efforts to develop in vivo gene editing therapies and contribute to the evaluation and identification of new targets. You will be responsible for the development and characterization of human cell-based assays and rodent models to evaluate the extent and effects of gene editing. The ideal candidate will have a diverse in vitro and in vivo experimental skill set with a strong background in primary cell culture and molecular biology, a track record of creative thinking, and a deep interest in genome editing. The successful candidate will be part of a dynamic, multidisciplinary discovery team dedicated to the development of gene editing-based therapies for major disease indications.
Key Responsibilities amp; Accountabilities:
· Lead assay development and implementation to demonstrate gene editing and impact on target expression in relevant human cell lines and primary human cells in vitro and target tissues in vivo.
· Plan and execute mouse experiments to inform in vivo activity of drug candidates, including pharmacodynamic activity using biomarkers, efficacy readouts, and PK/PD properties.
· Perform in vitro or ex vivo assays to assess phenotype relevant to disease.
· Present technical and functional area knowledge to design experiments that contribute to the overall direction of project(s).
· Contribute to the exploration and identification of new targets and engage with cross-functional stakeholders to evaluate the probability of technical, clinical, and commercial success.
· Contribute to timeline, milestones, success criteria, MPP, and TPP development.
· Generate technical documents, SOPs, study reports and other forms of documentation for IND-enabling activities and procedure development.
· Suggest and implement changes to IACUC protocols.
· Synthesize literature, analyze, and present data within and outside the organization.
· Share responsibility in maintaining lab equipment and reagent inventory.
· Maintain electronic lab notebook in a timely fashion.
· Interact with vendors, collaborators, and internal teams for various functions.
Requirements
Knowledge, Skills amp; Capabilities:
· Expertise in mammalian cell culture, including primary cells, the development of cell-based assays, and molecular biology techniques.
· Must have hands on experience working with mouse models and be proficient in intravenous dosing and tissue harvesting.
· Experience with gene editing technologies and lipid nanoparticle delivery is highly desired.
· Outstanding communication skills, both written and oral, and an ability to work in a team-oriented, multidisciplinary environment.
· Experience mentoring research associates.
· Proven track record of collaborating with cross-functional teams to meet shared objectives.
· Track record of driving early-stage discovery programs through DC nomination desired.
· Industry experience a plus.
Education amp; Relevant Work Experience
· PhD in cell and molecular biology with 5-8 years of research experience, preferably 3 years in an industry setting.
Benefits
Benefits Summary:
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.
Fostering Belonging. Fueling Innovation. Transforming Liv