Research Associate, Library Development Chemistry
Plexium, United States
Job Description
Plexium is a San Diego-based targeted protein degradation drug discovery company whose purpose is to discover and develop impactful therapies changing the course of human disease. We are a close-knit team of drug discovery and engineering experts using pioneering platform technologies to discover and develop transformative new drug modalities. Plexium has an open work environment with a positive, friendly, and collaborative culture. We are committed to fostering innovation and encouraging cross-functional collaboration and supporting the growth and development of our team members.
We are seeking a Research Associate Chemistry to be part our team developing synthetic chemistry protocols that will be used by our Library Production group to prepare libraries of compounds using solid-phase one-bead-one compound technology. The successful candidate will have:
- Experience in the safe handling of chemicals and reagents involving solution-phase and, preferably, solid-phase organic syntheses, parallel syntheses, reaction monitoring, reaction work-up and product isolation and characterization
- A good understanding of, and experience in, optimizing synthetic organic chemistry reactions and reaction sequences to produce libraries of compounds
- A good grasp of organic chemistry principles and good chemistry problem-solving skills
- Ability to organize own work and lab tasks to be safe and productive, following priorities and working to deadlines set by supervisor
- The ability to discuss and clearly communicate the chemistry they are undertaking to other members of the team
- Experience with DNA-encoded libraries would be beneficial.
Requirements
Qualification prerequisites MS degree in organic chemistry plus at least 2 years, or BS degree in chemistry plus at least 4 years, of lab experience in an industrial chemistry environment (e.g. the biotech or pharmaceutical industry)
Specific Responsibilities include:
- Designing DEL libraries that expand diversity coverage and deliver drug-like molecules
- Performing and optimizing individual reactions and reaction sequences in solution- or solid-phase synthesis
- Establishing the scope and limitations of reactions and conditions for their use in library chemistry, including establishing compatibility with DNA (for DNA-encoded libraries)
- Producing robust library production protocols that can be used by the Library Production team
- Contributing to establishing a seamless working interface with the Library Production team, the DNA sequencing group, drug discovery teams and other members of the chemistry department through a collaborative and flexible approach
Benefits
- Comprehensive medical, dental and vision coverage
- 401K
- Generous vacation policy
- Stock options