Scientist / Senior Scientist, Platform technology development
Generation Bio, United States
Job Description
Generation Bio is a biotechnology company leading a new generation of gene therapy. With our proprietary re-dosable ceDNA technology, we are expanding the reach of gene therapy At Generation Bio, our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.
We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives.
Delve further. Please visit www.generationbio.com or follow @generationbio.
SUMMARY:
Generation Bio is seeking an energetic and highly motivated molecular biologist(s) with expertise in the one or more of the following areas 1) High-throughput pooled screening techniques 2) Aptamer technology development 3) ribosome profiling and 4) nucleic acid cell biology/ host interactions. As part of our Platform biology team, the scientist hired will discover and apply new approaches to the development of our novel ceDNA gene therapy technology. The role is cross-functional, with key interactions with bioinformatics, pre-clinical , manufacturing and formulation teams.
RESPONSIBILITIES:
- Conceive and execute experiments to inform ceDNA optimization amp; technology development strategies
- Analyze construct performance and molecular attributes in vitro
- Analyze complex datasets in order to design and optimize constructs
- Utilize modern synthetic biology approaches to develop and implement strategies for vector and library construction.
- Oversee and manage day-to-day activities of Research Associates
- Work with a cross functional team including pharmacology and bioinformatics
- Manage CRO activities, including project design, timelines and quality of deliverables
QUALIFICATIONS:
- PhD in Molecular Biology, Virology, Mammalian Cell Biology, Biochemistry or related discipline
- Minimum of 1-2 years of industry experience preferred
- Fluency and extensive hands-on experience with molecular biology techniques with a focus on application to mammalian systems
- Experience with one or more of following methods is required - Ribosome profiling, Host cell DNA-protein interaction studies, Aptamer engineering/ development, NGS-based pooled genetic screening
- Experience/ knowledge of AAV constructs, a plus
- Experience with bioinformatic analysis (e.g. Database curation/mining, Sequence analysis techniques and statistical evaluation of high-dimensional data sets), a plus
POSITION: Full-Time, Exempt
EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.