Scientist/Senior Scientist, Genome Engineering
BlueRock Therapeutics, United States
Job Description
Senior Scientist, Genome Engineering
Who is BlueRock?
BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.
The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing?
Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.
We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.
We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients’ lives.
Description of Position:
The Cambridge, MA, USA site is seeking a Sr. Scientist for the Genome Engineering pipeline that will report to the Vice President of Platform Development. The incumbent will manage a dynamic and progressive team pioneering the design and production of genome-modified therapeutic cells from human pluripotent stem cells (hPSCs). The candidate will lead a small team that will work closely with Immunology to help design and build cell lines for Immune Evasion and the Immune Cell Therapy programs. On the platform side, the ideal candidate will create an automated solution to rapidly build and test new genome designs.
Responsibilities:
- Execute in vitro experiments to characterize and cultivate hPSCs and their derivatives.
- Assist in the design and construction of plasmids for genetic modification.
- Apply gene editing technologies including CRISPR/Cas9 in hPSCs.
- Perform DNA/RNA-based, cell-based, flow cytometric, immunofluorescence and other analytical assays as required.
- Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
- Be responsible for data generation, collection, interpretation and communication of results.
- Prepare and follow standard operating procedures, batch records and other process documentation.
- Attend and present scientific data to colleagues at internal meetings.
Minimum Requirements:
- Ph.D. in immunology, cell biology, molecular biology, genetics or related discipline, with 5-8 years laboratory research or industry experience.
- Experience with molecular cloning and gene editing technologies.
- Experience with cell characterization technologies including PCR, DNA sequencing, qPCR, flow cytometry and immunofluorescence.
- Industry experience preferred.
- Experience with human pluripotent stem cell or mammalian cell culture preferred.
- Experience with high-throughput equipment and methods preferred.
- Experience with hPSC transfection/nucleofection techniques preferred.
- Experience with DNA design software is preferred.
- Excellent analytical, problem solving and organizational skills.
- Strong written and verbal communications skills.
Equal Opportunity Workplace:At BlueRock, we welcome and support differences and diversity and we are proud to be an equal opportunity workplace. Please let us know if you require disability-related accommodation or other grounds protected by human rights legislation during the recruitment process so that we can work with you to meet your needs.