Senior/Principal Research Associate In vivo Sciences (Neurology, Histology)
BlueRock Therapeutics, United States
Job Description
Who is BlueRock?
BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.
The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing?
Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.
We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.
We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients’ lives.
Description:
BlueRock Therapeutics is seeking a talented, highly motivated Research Associate for our In vivo Sciences team in New York, City. The successful candidate will be a key technical contributor of a dynamic and progressive team developing novel therapeutics. This challenging opportunity requires in depth knowledge of neurodegenerative diseases as well as stem cell biology. The ideal candidate will be a highly motivated individual who leads from the bench and enjoys having broad responsibilities and opportunities. The ability to effectively communicate with internal team members is critical. Collaboration with a highly-motivated, world-class team of scientists and engineers promises an exciting and engaging work environment for motivated, self-starting candidates. Familiarity with cGMP aseptic manufacturing regulations is a plus.
Responsibilities:
- Perform stereotactic surgeries, immune assays and microscopic acquisition to help broaden our understanding of how our therapies function using preclinical disease model.
- Perform histology, neuropathology assessment supporting preclinical study of our cell products.
- Establish and organize tissue and slide archive for the in vivo science team
- Establish and maintain new tissue processing and staining SOPs
- Collect fluid and tissue from animal model for genetic analysis by PCR and flow-cytometry.
- Collect and analyze data from various assays, track and trend data, and establish specifications for critical process controls.
- Present scientific data to colleagues in group meetings, prepare and present internal and external presentations (presentations, posters, publications).
- Perform additional duties to support the safe and efficient operation of the laboratory, and other duties as assigned.
Requirements
- Bachelors (gt;5 years) or Masters (gt;3 years) in biological sciences with full time hands-on in vivo experience, experience with pathology/microscopy core is a strong plus.
- Proficient in animal dosing and handling techniques, collection of blood, tissue harvesting and processing, sectioning, immune assay, microscopic acquisition.
- Experience with standard testing equipment and procedures including, but not limited to, stereotaxic injection, IHC/immunofluorescence microscopy, and whole slide scanners. Familiarity with stereological microscopy or automated/advanced image analysis, tissue clearing technique is a strong plus.
- Experience collecting and analyzing biological data using programs such as ZEN, LAS, MBF. MS Office suite is a necessity.
- Maintain well-organized records and documentation, data entry and analysis.
- A proven ability to be highly productive and successful in a high pace work environment with excellent attention to details and meticulous bench work.
- Self-motivated and willing to accept temporary responsibilities outside of initial job description.
- Good interpersonal, verbal and written communication skills.
- There is a risk of potential exposure to chemicals and biohazards consistent with somatic cell therapy.
- Working in the