Monte Rosa Therapeutics is seeking a highly skilled and motivated Proteomics Senior Scientist with drug discovery experience to join its growing Proteomics global team. This is an exciting opportunity to join a team responsible for the characterization of novel small molecule glue-based degraders to support Monte Rosa’s growing pipeline. The successful candidate will be responsible for building out Proteomics operations in Boston, providing both scientific leadership and hands-on technical expertise. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional multi-disciplinary drug discovery teams and have experience managing direct reports.
Principal Duties and Responsibilities:
Responsible for the implementation and development of the Proteomics platform in Boston
Responsible for independently performing TMT quantitative proteomics experiments from sample preparation, LC-MS/MS, to data analysis, interpretation, and presentation of the proteomics results
Collaborate on projects with multi-disciplinary teams involving Biologist, Chemist, and Data scientists
Evaluate and implement new technologies/methodologies that may enhance proteomic workflows
Report data, interpret results, and present at project team meetings.
Requirements
Ph.D. in analytical chemistry, biochemistry, or related field
At least 5 years’ experience in proteomics in Pharma, Biotech or equivalent
Extensive hands-on experience in TMT quantitative proteomics methodology
Hands-on experience in protein post-translational modification analysis, protein-protein-interaction analysis, and targeted mass spectrometry analysis would be an advantage
Hands-on experience and strong troubleshooting skills for HPLC and orbitrap mass spectrometer instrument
Experience in processing proteomics data, with Mascot, Proteome Discoverer, Maxquant, Skyline, Scaffold
Excellent communication, data presentation and visualization skills both verbally and in writing
Highly collaborative and able to work in a matrix-type, interactive, and fast-paced drug discovery environment