Associate Scientist / Senior Associate Scientist, Preclinical Research
Generation Bio, United States
Job Description
Generation Bio is a biotechnology company leading a new generation of non-viral gene therapy. With our proprietary re-dosable ceDNA technology, we are expanding the reach of gene therapy. At Generation Bio, our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.
We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives.
Delve further. Please visit?www.generationbio.com?or follow?@generationbio.
SUMMARY:
Generation Bio seeks an energetic, versatile, and highly motivated associate/sr. associate scientist to join our Preclinical Research group. For this lab-based position, the successful candidate will support our antibody gene therapy platform and preclinical development of our growing pipeline of development candidates. The ideal candidate will have a background in research and development of biologics with experience in their characterization and expression in vitro. This role will be primarily responsible for implementing biochemical and cell-based assays for antibody gene therapy therapeutic lead selection as well as supporting efforts to optimize recombinant antibody expression.
RESPONSIBILITIES:
- Carry out molecular and cell biology experiments, including but not limited to, DNA cloning, transient transfections, electrophoresis, cell culture maintenance
- Optimize and execute plate-based assays to assess expression (e.g. ELISA, RT-qPCR, Western Blot) amp; functional activity (e.g. target engagement, enzyme activity, signaling pathway activation/inhibition) from tissue samples, plasma/serum, and cell culture.
- Design experiments, analyze data amp; interpret results
- Summarize studies in written reports and oral presentations
REQUIREMENTS:
- B.S. or M.S. with 2+ years of relevant industry experience (preferred)
- Excellent lab technique and the ability to work independently to analyze, interpret, and present data
- Proficient in protein detection methods including ELISA, MSD, and Western Blot analysis from both in vivo (tissue/plasma/serum) and in vitro (cells) samples
- Proficient with cell culture manipulation techniques (e.g., transfections, cell-based assays)
- Experience running in vitro assays to assess binding affinity (e.g. Octet, Biacore) is a plus
- Experience with DNA/RNA purification and quantification, biochemical assays, enzymatic assays, and/or cell imaging methods (e.g. IHC, FACS) is a plus
- Ability to multi-task to support multiple projects across platform and disease biology pharmacology
- Ability to work in a highly collaborative, cross-functional environment
- Excellent written and verbal communication skills
- Prior experience with gene therapy and/or lead optimization a plus
POSITION: Full-Time, Exempt
EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.