Editas Medicine is seeking a highly motivated Research Associate I/II to join our iPSC Engineering team and advance Editas’ cell-based medicines portfolio. In this role, you will contribute to generate pre-clinical and clinical genetically engineered induced pluripotent stem cell (iPSC) lines and develop a clinically compatible, cutting-edge platform to edit, isolate and characterize clonal cell banks. The ideal candidate should have a background in gene-editing, cancer biology and a solid cell culture experience. Automation of cell culture, including the use of liquid handling robots and microplate handlers will be involved. The successful candidate will perform his/her responsibilities both at the Cambridge location and at a cleanroom in Waltham and will interact with the Sequencing, Quality and CMC/manufacturing teams as well as iPSC differentiation and genotoxicity groups. The successful candidate should demonstrate strong work ethic and enjoy working in a fast-paced and team-oriented work environment.
Key Responsibilities
- Culture, maintain, and bank iPSC lines for research team and clinical CMC team that will eventually be used to produce GMP material
- Perform gene-editing of iPSC using established protocols developed by the team.
- Design experiments, analyze and present data within the organization.
- Perform basic molecular biology work such as DNA extraction and PCR.
- Work as part of a team, adhere to protocols, and maintain detailed documentation.
- Share responsibility in maintaining lab equipment and reagent inventory.
- Maintain an electronic lab notebook and contribute to support documentation
Requirements
Minimum Qualifications
- BS/MS in cell biology, molecular biology or related field with 1-3+ years of laboratory experience
- Excellent oral and written communication skills.
- Excellent interpersonal skills and team-oriented player
- Expertise in mammalian cell culture (experience with culture of human iPSC is desired)
- Competency in basic cellular and molecular biology techniques including PCR, ddPCR, Flow Cytometry.
- Independently motivated, detail oriented and excellent problem-solver
- Outstanding organizational skills, and ability to multi-task in a fast-paced environment