Research Associate II, Ex Vivo Pharmacology
Editas Medicine, United States

Key Responsibilities amp; Accountabilities:

• Assist with the establishment and maintenance of mouse tumor models to test the efficacy and MOA of cellular cancer therapies
• Perform mouse in vivo animal procedures, including tumor inoculation and dosing mice by various routes (IP, IV, SC, etc.), serial blood collections, tissue harvesting at necropsy, and data collection
• Monitor in-life study measurements: measure tumors by calipers and non-invasive bioluminescent imaging (IVIS), body weights, make detailed observations of tumor growth and mouse health
• Perform cell culture, including passaging, expanding, cryopreservation, thawing and processing of tumor cells
• Organization of studies: timing of in vitro tumor culturing, tumor implantation, randomization, and handling/processing cellular therapies for dosing
• Experience with multi-parameter flow cytometry (FACS) analysis is preferred
• Share responsibilities in maintaining lab equipment and reagent inventory
• Follow laboratory safety guidelines and practices
• Analyze data and effectively communicate experimental results to research scientists
• Maintain a meticulous electronic lab notebook and contribute to support documentation

Requirements

Knowledge, Skills amp; Capabilities:

• Expertise in mammalian cell culture necessary (experience with culture of primary human cells is desired)
• Experience in direct mouse handling and performing pharmacology related tasks including dosing, survival blood collections, tumor cell inoculation/measurements, tissue harvesting at necropsy, etc.
• Independently motivated, detail oriented and excellent problem-solver
• Ability to work with cross-functional teams in a fast-paced environment

Education amp; Relevant Work Experience:

• BS/MS in Biology or related discipline.
• 2+ years of relevant research experience in an academic or pharmaceutical/biotech vivarium. Background in immuno-oncology is preferred

Job Rewards and Benefits