Principal Scientist/Associate Director, Computational Chemistry
Neuron23, Inc., United States

Experience
1 Year
Salary
0 - 0
Job Type
Job Shift
Job Category
Traveling
No
Career Level
Telecommute
No
Qualification
As mentioned in job details
Total Vacancies
1 Job
Posted on
Apr 21, 2021
Last Date
May 21, 2021
Location(s)

Job Description

Neuron23 Inc. is an early-stage biotechnology company focused on developing precision medicines for genetically defined neurological and immunological diseases. Neuron23 leverages recent advances in human genetics, combined with their state-of-the-art artificial intelligence (AI)-enabled drug discovery and biomarker platforms, to advance therapeutics for devastating diseases. The company’s focus areas are neurodegenerative diseases, neuroinflammatory diseases, and systemic autoimmune and inflammatory diseases. Founded in 2018, Neuron23 has assembled a world-class team of experts and entrepreneurs located in South San Francisco, CA, and Munich, Germany. For more information, please visit www.neuron23.com.

The Company’s culture is driven by a philosophy of collaboration and innovation, starting with an executive team tasked with navigating development paths in partnership with key stakeholders, scientific and industry associations, and regulatory agencies worldwide. We invite you to consider an opportunity with Neuron23 to help achieve our goal of delivering meaningful therapeutics to patients.

RESPONSIBILITIES

  • Drive computation chemistry at Neuron23 to facilitate drug discovery projects, from lead identification to lead optimization to candidate selection. Play a lead role in HTS hit triage, lead optimization SAR analysis, structure-based design, off-target selectivity analysis, physiochemical and ADME property analysis and prediction.
  • Responsible for developing and implementing computational tools in silico drug discovery applications encompassing all aspects of cheminformatics, structure-based and ligand-based methods, virtual screen, analysis of large biological assay data sets, as well as developing novel computational tools and solutions that will enable Neuron23’s drug discovery efforts.
  • Work with project chemists to analyze ligand-protein interaction, generate hypothesis to improve ligand design.
  • Help project teams to triage HTS hits and lead optimization.
  • Collaborate and contribute within drug discovery team settings.
  • Developing and delivering scientific reports and presentations internally or externally as needed
  • Keep abreast of computational field.

Requirements

QUALIFICATIONS:

  • Ph.D. in computational chemistry, Chemoinformatics, CADD, or chemistry with 5+ years of industry experience and proven track record in one or more of the areas: structure-based design for lead discovery and lead optimization, docking studies, virtual screening, drugability analysis, molecular dynamics simulation.
  • Solid understanding of ligand-protein interactions
  • Flexibility in fast paced startup environment for early stage biotech’s
  • Experience in implementing and leveraging a range of computational methods applied to lead optimization and to drug discovery.
  • A track record of communicating scientific concepts effectively, including a publication record in top-tier, peer reviewed journals.
  • Ability to creatively solve problems and think critically while influencing fast-paced research teams
  • Expertise in cheminformatics is a plus.
  • Knowledge and experience in Machine learning and/or artificial intelligence applied to drug discovery is a plus.

Benefits

Neuron23 is proud to be an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status.

Job Specification

Job Rewards and Benefits

Neuron23, Inc.

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