Associate Scientist/Senior Associate Scientist, Adoptive Cell Therapy
KSQ Therapeutics, United States
Job Description
At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.
Founded in late 2015, KSQ is a preclinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development. We maintain a lively and inquisitive environment in the heart of the vibrant Kendall Square neighborhood.
Position Summary:
KSQ Therapeutics, Inc. is seeking a self-motivated and dependable Associate Scientist/Senior Associate Scientist to join our Adoptive Cell Therapy team. Our ideal candidate thrives in a research environment that demands scientific rigor and technical excellence. Applicants with an interest in T cell immunology and expertise in cell culture, CRISPR-Cas9 technology and cell biology are strongly encouraged to apply.
The (Senior) Associate Scientist’s key responsibilities will include the following:
- Contribute to the development of KSQ’s engineered (e)TIL (Tumor Infiltrating lymphocytes) pipeline
- Design and execute cell-based functional assays for the validation of T cell therapy edits
- Develop and deliver scientific presentations and reports in a fast and efficient manner
- Participate in cross-functional team collaborations
- Participate in various aspects of small company capability building
Requirements
- B.S. or M.S. in biology, immunology, or relevant field
- 1-3 years of experience in a relevant academic or biopharmaceutical setting
- Proficiency in mammalian cell culture and aseptic cell culture techniques
- Experience in designing, performing, and interpreting the results of multicolor flow cytometry for phenotyping and functional analysis of immune cells required
- Hands-on experience in diverse cell biology techniques (cell isolation, proliferation assays, T cell expansion, cytotoxicity, functionality assays and etc.) and molecular biology techniques
- Experience in CRISPR/Cas9 gene-editing tools and cloning techniques is a plus
- Demonstrated commitment to quality and great attention to details
- Excellent verbal/written communication and presentation skills
- Ability to contribute to multiple parallel projects under demanding timelines
- A record of achievement in research and scientific creativity in the areas of immunology, oncology, inflammation, immuno-oncology, and/or drug discovery