Sr. Research Associate, Process Development

Sr. Research Associate, Process Development
BlueRock Therapeutics, United States

Experience
1 Year
Salary
0 - 0
Job Type
Job Shift
Job Category
Traveling
No
Career Level
Telecommute
No
Qualification
Bachelor's Degree
Total Vacancies
1 Job
Posted on
May 5, 2021
Last Date
Jun 5, 2021
Location(s)

Job Description

Who is BlueRock?

BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.

The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.

What Are We Doing?

Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.

We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.

We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients’ lives.

Description of Position:

BlueRock Therapeutics is seeking a Senior Research Associate, Process Development to join our newly opened lab space in Cambridge, MA. If you’re a key scientific contributor looking for a unique and diverse role encompassing several elements of the manufacturing process, look no further! From process development and analytics through to clinical manufacturing, this role covers a broad scope and involvement in the process from end-to-end. This position will collaborate with the team to develop, scale up the end-to-end manufacturing process and produce the clinical supply of authentic and engineered cellular products. With exciting pipelines and tremendous potential, this is an opportunity for a talented and self-motivated Research Associate to contribute to bringing cutting-edge cellular therapies to patients while gaining valuable career experience in Process Development.

Responsibilities:

  • Participate and lead design and execution of lab scale experiments to develop, optimize and characterize scalable processes for cultivation of iPSC, and differentiated cellular products
  • Identify and determine appropriate ranges for (critical) process parameters for cell culture and downstream processing to optimize product yield and quality
  • Develop and optimize processes and systems to scale up production of PSCs and derivatives in a cGMP compliant manner
  • Perform clinical manufacturing supply of cellular products according to cGMP standards and SOPs.
  • Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
  • Prepare and follow cGMP standard operating procedures, batch records and other process documentation
  • Present scientific data to colleagues at internal meetings.

Requirements

  • Bachelor or MSc. in biomedical engineering, biological sciences, or similar
  • BS 5-7+ / MS 3-6+ years of experience, preferably in an industry setting
  • Hands on experience with bioreactors and cell processing technologies
  • Extensive mammalian cell culture and cell characterisation experience, ideally with PSCs and cardiomyocytes
  • Familiarity with cell characterisation methods and technologies (e.g., flow cytometry, qPCR, immunoassays, microscopy) is desirable
  • Hands on experience with automation platforms (liquid handlers) for cell culture and assay development is desirable
  • Demonstrated ability to plan experiments and independently execute complex tasks
  • Practical knowledge of experimental design (e.g., DoE) and statistical analysis of data
  • Strong English written and verbal communications skills
  • Proficiency in technical scientific writing

Work Environment

  • In this position you will work in a controlled laboratory environment
  • You may be periodically required to move heavy equipment up to 50lbs
  • There is a risk of potential exposure to chemicals and biohazards consistent with somatic cell therapy culture
  • Working in th

Job Specification

Job Rewards and Benefits

BlueRock Therapeutics

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