Cellular Process Development, Scientist

Cellular Process Development, Scientist
KSQ Therapeutics, United States

Experience
1 Year
Salary
0 - 0
Job Type
Job Shift
Job Category
Traveling
No
Career Level
Telecommute
No
Qualification
As mentioned in job details
Total Vacancies
1 Job
Posted on
May 10, 2021
Last Date
Jun 10, 2021
Location(s)

Job Description

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a preclinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development. We maintain a lively and inquisitive environment in the heart of the vibrant Kendall Square neighborhood.

Description

The individual in this role is responsible for providing expertise to enable process development and process characterization of KSQ cell therapy products. The scope of the role spans early-stage process development through technology transfer for clinical manufacturing.

Requirements

Process Development

  • Provides subject matter expertise, project leadership, and critical laboratory support for process development activities in preparation for technology transfer to CDMO
  • Author and review technical/development reports and protocols
  • Provide timely updates and compile data summaries to inform decision-making
  • Design and execute experiments involving the isolation, engineering, expansion, and cryopreservation of gene modified T cells for the treatment of solid tumor malignancies
  • Analyze data, interpret scientific results, and present scientific data to key internal stakeholders
  • Independently manage and execute on key project workstreams while working collaboratively with members from other functional groups including research, analytical development, and quality.
  • Order project-specific reagents and maintain equipment
  • Mentor and guide junior scientists in the design and execution of their work and career development, may manage one associate
  • Generate and maintain critical data in a highly organized manner
  • Compile and present data to functional team and leadership as required
  • Responsible for coordinating critical reagents as needed to support laboratory activities
  • This is a hands-on position and requires the candidate to have a flexible schedule based on experimental and company needs (including possible weekend work)
  • A BS/MS degree in chemical engineering, biotechnology, biology, or related discipline with 6+ years of relevant industry experience
  • Expertise in primary human immune cell isolation techniques and familiarity with common cellular therapy equipment such as Sepax, LOVO, controlled rate freezers, and CliniMACS is preferred
  • Previous experience in Process Development with demonstrated understanding of GMP principles, IHC guidelines, and technology transfer is preferred
  • Expertise in gene modification of primary cells using CRISPR/Cas9, mRNA transfection, or lentiviral/gamma-retroviral vector transduction
  • Expertise with standard immunological and functional assays such as multi-parameter flow cytometry, Luminex/ELISA/MSD, and cytotoxicity assays
  • Expertise with standard molecular biology techniques, including but not limited to: PCR, RT-PCR, qPCR, and Western blot
  • Must possess strong organizational skills, attention to detail, and the ability to adapt to changing priorities in a fast-paced environment
  • Ability to manage priorities and make decisions in a fast-paced environment to ensure deliverables are completed in a timely fashion
  • Excellent communication skills and ability to handle confidential information and material appropriately
  • Excellent computer skills, including Microsoft Excel and PowerPoint, GraphPad Prism, and FlowJo

Technical Operations Infrastructure

  • Establish Cellular Process Development (CPD) best practices for planning, executing, and documenting work (e.g., work practices, templates, etc.) as we work to continuously improve as a team
  • Lead risk-based assessments such as RCA and FMEA

Basic Laboratory

Requirements

Job Specification

Job Rewards and Benefits

KSQ Therapeutics

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