Research Associate I, Biological Development
Editas Medicine, United States

Key Responsibilities amp; Accountabilities:

• Develop and optimize protocols for gene editing, including: delivery methods, culture conditions, scale up, and multiplexing
• Characterize genetically modified primary cells using standard immunological assays including flow cytometry, imaging, immunofluorescence
• Develop and perform immune cell activation, cytotoxicity, and other cellular and ELISA-based assays to evaluate gene editing approaches that improve the efficacy of effector cell therapeutics in vitro and in vivo
• Share responsibility in maintaining lab equipment and reagent inventory.
• Analyze and present experimental data to laboratory staff and larger program meetings
• Management of external CRO’s
• Maintain an electronic lab notebook and contribute to support documentation

Requirements

Knowledge, Skills amp; Capabilities:

• Must have experience with mammalian cell culture including primary hematopoietic cells
• Strong preference for individuals with demonstrated knowledge of immune cell activation, cytotoxicity, and other cellular and ELISA-based assays to evaluate gene editing approaches in cell therapeutics in vitro and in vivo
• Experience in gene-editing (CRISPR/Cas9) will be a plus
• Experience in multi-color flow cytometry and cell-based assays such as flow cytometric analysis of blood cells desirable
• Result-driven with excellent attention to details and ability to independently execute protocols
• Experience troubleshooting assays, including consulting the available literature for potential precedent
• Excellent written and oral communication skills
• Ability to work in a team-oriented, multidisciplinary environment

Education amp; Relevant Work Experience:

• BS or MS in cell biology, immunology, or related field with 0-2 years of research experience

Job Rewards and Benefits