Principal Research Associate, Chemistry
Editas Medicine, United States

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

Key Responsibilities amp; Accountabilities:

• Perform reverse phase purification on a variety of scales and instruments including the Gilson prep purification system and Agilent semi-prep purification system.
• Perform process development, scale up and process optimization.
• Conduct ultrafiltration, lyophilization and other downstream post-synthesis work-up procedures.
• Perform various analytical techniques to ensure final product meets specifications including LCMS, UPLC and UV spectroscopy.
• Perform instrument and equipment preventative maintenance and repairs.
• Maintain an electronic laboratory notebook and miscellaneous documentation.
• Maintain reagent inventory.

Requirements

Knowledge, Skills amp; Capabilities:

• Experience in reverse phase purification, ultrafiltration and lyophilization of oligonucleotides.
• Experience with laboratory automation.
• Excellent oral and written communication skills.
• Proficient with Microsoft Office programs.
• Ability to work effectively in a cross-functional team environment.
• Technical troubleshooting and organizational skills.
• Excellent time management.

Education amp; Relevant Work Experience:

• Requires a Master’s Degree or equivalency in Chemistry or related Life Science Degree with a minimum five years of relevant experience or a Bachelor’s Degree or equivalency in Chemistry or related Life Science Degree with a minimum eight years of relevant experience.

Job Rewards and Benefits