Senior/Principal Research Associate, Immunology, In Vivo
BlueRock Therapeutics, United States
Job Description
Who is BlueRock?
BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique CELL+GENE platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.
The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel CELL+GENE platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing?
Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.
We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.
We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients’ lives.
Description of Position:
BlueRock Therapeutics, Cambridge location is expanding, and a key position to be hired is a Senior/Principal Research Associate, in vivo within the Immunology group. This position will have various responsibilities for hands-on in vivo work developing macrophage and T cell programs. This is an outstanding opportunity for a talented and self-motivated person to contribute to bringing cutting-edge cellular therapies to patients while gaining valuable career experience in translational Immunology.
Responsibilities:
- Participate in the execution of in vivo experiments in multiple models across diverse therapeutic areas including autoimmunity, transplantation, and oncology (xenograft models, PDX models, humanized models)
- Execute efficacy, toxicity, biodistribution, and PK/PD in vivo studies under supervision
- Animal manipulation, sample collection, as well as processing and analysis of blood and tissue samples using a variety of techniques, including flow cytometry, ELISA, Luminex, Elispot, and other molecular and cell biology techniques
- Conduct live-animal bioluminescent imaging and analysis
- Assurance compliance with protocols, interacts with the IACUC for protocols, amendments
- Analyzing, reviewing, and presenting data within group and across-functionally at department meetings
- Comply with standard laboratory practices and company policies, including notebook document and biosafety policies.
- Maintain scientific curiosity and familiarity with relevant literature and cutting-edge technologies to advance research directions
Requirements
Minimum Requirements:
- BS and MS in Immunology, Immuno-Oncology, Transplant Immunology or related discipline is required
- A BS in relevant discipline with minimum of 5~7years of relevant experience, or MS in a relevant discipline with an additional 3~6 years of experience.
- proven proficiency in execution of in vivo experiments as well as sample collection, processing, and assessment using variety of laboratory techniques
- Proficient with multiple routes of injection (i.m., i.p., i.v., etc) and administration in murine models, as well as blood and tissue collection techniques. Experience in intracranial injection is a plus.
- Familiarity and experience strongly preferred with bioluminescent live-imaging techniques using an IVIS type system or equivalent
- Experience with characterization and assay of immune cell population and cytokines using state-of-the-art-techniques (e.g., FACS, Luminex, Elispot, ELISA, etc.)
- A strong self-starter, independent thinker, with a strong attention to detail.
- Experience in mouse models of inflammatory diseases, autoimmunity, or cancer, is preferred. Experience in humanized mice is a plus.
- Familiarity with T cell or macrophage based therapeutic development and evaluation. Hands on experience with those models is preferred.
- Effective communicator with excellent interpersonal and organizational skills is required
- Ability to work productively in a fast-paced, team environ